What in your opinion is the best entrepreneurial advice for somebody venturing into self-employment in the present situation?
Why do you want to be self-employed in the first place? Being laid off and broke is normally not a great time to start a business unless you have a great idea and the capital to launch.
MY BEST ADVICE
Geta job (assuming you need income) and start a business in your free time as this forces you to manage your time well and gives you an incentive to get this business off the ground so you can quit your job.